Summary
Long-read RNA sequencing enables the analysis of complete transcript structures, thus allowing for granular transcriptome analysis. There is growing interest in RNA isoform diversity as both a cause of disease and a therapeutic target, particularly for diseases of the central nervous system (CNS).
It is becoming increasingly clear that there are high cell type biases in transcript use in the human brain, which could be utilized for targeting therapies. This has occurred simultaneously with advances in antisense oligonucleotide (ASO) technologies, which enable precise targeting of transcripts.
Project aims
The aim of this PhD would be to use long-read RNA-sequencing to analyse cell type-specific transcript use across major brain cell types to improve the design and development of inherited disorders neurological disorders.
Contact details
Professor Mina Ryten - mr2022@cam.ac.uk
Opportunities
This project is open to applicants who want to do a:
- PhD